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-n',-' 1I~ (J) Fig. mbCD therefore decreases both clathrin- and caveolae-mediated uptake. 238 233 227 212 207 204,205 187,188 185 179,180 164 161 155 152 143 137 116 110 106 ~22 nt 22 nt 21 nt 21 nt 9 nt 23 nt 21 nt 21 nt ~21 nt 22 nt Cleavage Forec separation Targeted cleavage CBA OH 0 20 60 0 20 60 0 20 60 min dsRNA Cleavages of mRNA in RNAi occur at 2123-nt Figure 16.
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