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3-q34 Ligands EGF, TGF, amphiregulin, HB-EGF, betacellulin none NRG1, NRG2 NRG1, NRG2, NRG3, NRG4, betacellulin, HB-EGF Remarks heterodimerization partner of other family members lacks tyrosine kinase activity Table 18. References 1. The mortality rate is still substantial ( vs in most studies) and is highest in patients with underlying biliary malignancy or severe multiorgan dysfunction.

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